penicillinase type I from*bacillus cereus
beta-lactamase F. enterobacter cloacae
CAS: 9001-74-5
Molecular Formula:
penicillinase type I from*bacillus cereus - Names and Identifiers
penicillinase type I from*bacillus cereus - Physico-chemical Properties
| Melting Point | 121-126°C |
| Appearance | powder |
| Color | white |
| Merck | 14,7093 |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Penicillinase is a white powder. Dissolved in water, the enzyme solution is easily inactivated. The dry product is stable at room temperature, and the freeze-dried product can be stable for one week at 2~8 ℃. The β-lactam ring that acts on penicillin converts penicillin into sterile active penicillin keto acid. 1h after intramuscular injection, the effect of penicillin quickly failed. The effect is maintained for at least 4 days, thereby subsiding the already produced penicillium allergy symptoms. |
penicillinase type I from*bacillus cereus - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 35079090 |
penicillinase type I from*bacillus cereus - Nature
Open Data Verified Data
The enzyme extracted from the culture filtrate of Bacillus cereus in this strain was white powder and dissolved in water. The dry product was stable at room temperature, and the enzyme solution was easily inactivated. The freeze-dried product can be stable for one week at 2~8 ℃. The relative molecular mass is about 50000. Action on the B- lactam ring of penicillin results in conversion of penicillin to penicillin ketoacid (penicillo-ic acid) with no antibacterial activity. After the intramuscular injection of th occurs, so that the rapid failure of penicillin, the role of at least 4 days, so as to resolve the allergic symptoms of penicillin has been produced.
Last Update：2024-01-02 23:10:35
penicillinase type I from*bacillus cereus - Use
Open Data Verified Data
- This product is suitable for allergic reaction to penicillin, and can also be used as adjuvant therapy for anaphylactic shock and severe allergic reaction to penicillin. Especially suitable for long-acting penicillin G allergic reaction.
- usage and dose of intramuscular injection, 800,000 units each time, once every 3~4 days; Intravenous injection, for anaphylactic shock, 800,000 units each time.
Last Update：2022-01-01 11:11:30
penicillinase type I from*bacillus cereus - Safety
Open Data Verified Data
(1) cannot be used for the allergic reaction caused by penicillin which is resistant to penicillinase, such as methicillin sodium salt, O-chlorbenzylisoxazole penicillin sodium and carboquine penicillin. (2) Note the red and swollen, occasionally Fever, chills, rash, Fatigue, Dyspnea, rare anaphylactic shock, multiple use can cause allergic reactions, a course of treatment should not exceed 3 times.
Last Update：2022-01-01 11:11:31